Carbidopa is the drug given to people suffering from Parkinson’s disease. The drug basically inhibits the peripheral metabolism of levodopa. Parkinson’s symptoms basically refer to stiffness, difficulty moving and shakiness of the body.
Parkinson’s disease is said to be a neurogenerative disorder of the extrapyramidal nervous system. It negatively impacts the control and mobility of the skeletal muscular system. Moreover, eradication half-life of levodopa augments in the survival of carbidopa is around 1.5 hours.
Carbidopa inhibits an enzyme known as aromatic-L-amino-acid decarboxylase. This enzyme is essential in the biosynthesis of L-DOPA to dopamine. In addition, the drug plays a vital role in the biosynthesis of L-tryptophan to serotonin.
Carbidopa is a chief inhibitor of aromatic amino acid decarboxylation. It is generally used as a technique to inhibit the act of dopamine decarboxylase. Further, it breaks down L-Dopa in the margin and later alters it to dopamine.
It leads to newly formed dopamine being incapable of crossing the blood-brain barrier. It can also lead to the remarkable decrease of L-Dopa treatments. Moreover, it augments the concentration of dopamine and L-DOPA in the brain.
Carbidopa also decreases the amount of levodopa needed to form a given response around 75%. The product can also be significantly utilized in combination with 5-HTP, driving global carbidopa industry.
Side effects of carbidopa are extremely uncommon. It basically occurs owing to levodopa- consisting product that is carried together with it. Some of the side effects are trouble sleeping, vomiting, nausea, dizziness, headache, and loss of appetite.
The medication may cause urine, sweat or saliva turn in a dark color. Carbidopa also finds use with levodopa to cure the muscle symptoms same as Parkinson’s disease that is caused by certain drugs like perphenazine, chlorpromazine, fluphenazine, and others.
Table of Contents:
Chapter One Introduction of Carbidopa Industry
1.1 Brief Introduction of Carbidopa
1.2 Development of Carbidopa Industry
1.3 Status of Carbidopa Industry
Chapter Two Manufacturing Technology of Carbidopa
2.1 Development of Carbidopa Manufacturing Technology
2.2 Analysis of Carbidopa Manufacturing Technology
2.3 Trends of Carbidopa Manufacturing Technology